In patients with a history of hepatic impairment, alcoholism, or heart failure.In patients with an eGFR between 30 and 60 mL/min/1.73 m2.Stop this drug at the time of, or before imaging procedure: IODINATED CONTRAST PROCEDURE: See Dosage Adjustment Section Dose AdjustmentsÄ®lderly, debilitated, and malnourished patients: Titration to the maximum dose is generally not recommended. Not recommended in patients with liver impairment IODINATED CONTRAST PROCEDURE: See Dosage Adjustment Section Liver Dose Adjustments eGFR greater than 45 mL/min/1.73 m2: No dose adjustments recommended.eGFR that falls below 45 mL/min/1.73 m2 during therapy: Assess risks versus benefit of continued therapy.eGFR that falls below 30 mL/min/1.73 m2 during therapy: Discontinue therapy.eGFR 30 to 45 mL/min/1.73 m2: Initiating therapy is not recommended.eGFR less than 30 mL/min/1.73 m2: Use is contraindicated.Use: To improve glycemic control in children with type 2 diabetes mellitus as an adjunct to diet and exercise. Titrate slowly to minimize gastrointestinal side effects.Dose titration: Increase in 500 mg increments weekly based on glycemic control and tolerability.Initial dose: 500 mg orally once a day with evening meal Dose titration: Increase in 500 mg increments weekly as tolerated daily dose should be taken in divided doses 2 to 3 times a day with meals.Use: To improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. Extended-release (ER): Take with the evening meal if glycemic control is not achieved with ER 2000 mg once a day, may consider splitting daily dose to ER 1000 mg twice a day if glycemic control is still not achieve, consider switch to immediate-release product.In general, significant responses are not observed with doses less than 1500 mg/day and doses above 2000 mg are generally associated with little additional efficacy and poorer tolerability. Immediate-release: Take in divided doses 2 to 3 times a day with meals titrate slowly to minimis gastrointestinal side effects.Metformin, if not contraindicated, should be considered first line-therapy for the management of type 2 diabetes mellitus.Patients receiving immediate-release may switch to extended-release once a day at same total daily dose (up to 2000 mg/day).Initial dose: 500 to 1000 mg orally once a dayÄose titration: Increase in 500 mg increments weekly as tolerated Maintenance dose: 2000 mg/day in divided doses Dose titration: Increase in 500 mg increments weekly or 850 mg every 2 weeks as tolerated.Initial dose: 500 mg orally twice a day or 850 mg orally once a day
0 Comments
Leave a Reply. |